The stars have been married for little over a year.
Johnny Depp and Amber Heard have announced they are set to end their short marriage.
Heard cited irreconcilable differences in formally filing for divorce from her Rum Diary co-star on Monday (May 23), according to gossip site TMZ.
The A-List couple tied the knot back in February 2015, in a low-key Los Angeles civil ceremony.
The pair met and fell in love while working together The Rum Diary – an adaptation of a novel by legendary journalist Hunter S. Thompson.
Earlier this year, Heard – who is bisexual – spoke out about her sexual orientation, saying it was not defined by her marriage to Depp.
The actress, who stars in the Danish Girl, came out in 2010 as she dated photographer Tasya van Ree.
She later married Depp – who last year said all of his characters are gay – and adopted his two children, but says marrying a man does not define her sexual orientation.
The actress has previously claimed that she has had to “fight” for movie roles since she coming out as bisexual.
She also says that she thinks celebrities who stay in the closet are “inadvertently admitting it’s wrong” to be gay or bisexual.
“I personally think that if you deny something or if you hide something you’re inadvertently admitting it’s wrong,” she said.
“I hate the idea of a label just as much as anyone else but I’m with who I’m with.
“I’m not a better actress than I was yesterday and my personal life should have no effect on that.”