Warren Beatty and Annette Bening’s 18-year-old child is reportedly living as a man and planning to transition.
The student is said to be known as Stephen Ira and wears men’s clothing to college.
The US tabloid magazine National Enquirer reports that acting pair Beatty, 73, and Bening, 52, are “devastated” by the news.
A source told the publication: “Warren Beatty is beside himself over the situation with his daughter Kathlyn.
“He and Annette have tried to deal with this over the years when their daughter was younger, but she’s determined to go ahead with the transgender operation, just like [Chaz Bono].
“She repeatedly told her parents that once she turns 18 she would take matters into her own hands.”
Beatty and Bening have been married for 18 years and have three other children. They have not commented on the reports.
Last year, Chaz Bono, the son of singer Cher, announced he was becoming a man after living as a lesbian for 20 years.
The 40-year-old recently legally changed his name and is thought to be nearing the end of his transition.